David P. Giedroc earned his B.S. (Biochemistry) from the Pennsylvania State University and obtained his Ph.D. (Biochemistry) under the supervision of J. David Puett at Vanderbilt University. He was an NIH postdoctoral fellow with the late Joseph E. Colman of Yale University and then established his own research group, first at Texas A&M University (1988-2007), and then at Indiana University, where he is currently Lilly Chemistry Alumni Professor in the Department of Chemistry.
Giedroc studies the inorganic chemistry of bacterial cells and is a pioneer in our understanding of transition metal homeostasis, the process that governs the correct metalation status of approximately 30 percent of the proteome. He was the first to develop and implement a physicochemical framework for exploring this problem by incorporating concepts of thermodynamic linkage and dynamics-driven allostery. More recent discoveries are foundational to the emerging field of hydrogen sulfide signaling, and Giedroc continues to elucidate how new sulfur chemistry and cellular reactive sulfur species impact bacterial physiology relevant to infections. Giedroc was named a faculty fellow at Texas A&M University (2001-08) and at Indiana University is founding director of the NIH Chemistry-Biology Interface (CBI) Training Program in Quantitative and Chemistry Biology (QCB) (2010-present) and past department chair (2010-15). Giedroc is current chair of the board of Metallomics, a publication of the Royal Society of Chemistry (UK) and is a fellow of the American Association for the Advancement of Science, the Royal Society of Chemistry, an OXIDE (Open Chemistry Collaborative in Diversity Equity) Diversity Catalyst Lecturer, and a fellow of the American Academy of Microbiology.
Giedroc received the IU Bicentennial Medal in September 2020 in recognition of his distinguished contributions to Indiana University.