Dr. Weber received his B.A. and M.D. from Queen's University, Kingston, Ontario, Canada, and has been in basic and clinical research since graduation. He is internationally known for his work in cancer research, particularly in biochemistry and chemotherapy. He is famous for his Molecular Correlation Concept which provided a rational paradigm for the interpretation of the enzymology of cancer cells, and he demonstrated the presence of a transformation- and progression-linked, ordered biochemical imbalance in animal and human cancer cells. His idea, that the increased activities of key enzymes should be sensitive targets to drug treatment, has been applied to the therapy of leukemia, where he, with his clinical colleagues, reported promising results in patients with chronic granulocytic leukemia in blast crisis. His clinical treatment of leukemia was confirmed independently at Boston University. In 2001 Dr. Weber received the prestigious Semmelweis Medal and Diploma from the Semmelweis University in Budapest in recognition of his work on signal transduction. He also received the Medal and Diploma of the Hungarian Gastroenterological Society for his studies on liver cancer (2002). Dr. Weber served as a visiting Professor at the University of Bologna, Italy (2001) and was British Cancer Campaign Professor at Oxford University, Oxford, U.K. (2000). He received the Prestigious External Award Recognition (2002) which honors IUPUI faculty members who have received international awards in the past year. Dr. Weber continues to serve as a Member of the Executive Committee of the I.U. Cancer Center (1993-present) and as a member of the President's Council on International Programs (1993-present) and on the Euro-Asian Committee at Indiana University (1990-present). Dr. Weber is internationally known for his studies on enzyme regulation. He is founder and chairman of Conferences on Enzyme Regulation held annually since 1962 at Indiana University School of Medicine; he is Editor of Advances in Enzyme Regulation, now in its 42nd volume. Dr. Weber has received honorary doctor degrees from the Universities of Chieti, Italy (1979), Budapest, Hungary (1982), Leipzig, Germany (1987), Tokushima, Japan (1988) and Kagawa, Japan (1992). The medical students at Indiana University twice voted him best Professor and he was given the Golden Apple Award.
Distinguished Professor Emeritus of School of Medicine