Dr. Malkas received an A.S. degree in Engineering, a B.S. in Chemistry and a Ph.M. and Ph.D. in Biochemistry from the City University of New York. She was a postdoctoral fellow at the Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts. She subsequently joined the faculty of the University of Maryland School of Medicine as an Assistant Professor in 1990.
During Dr. Malkas' tenure at Maryland she was the first to isolate and characterize a fully functional multiprotein complex from human cells that supports DNA replication in vitro. Dr. Malkas then demonstrated that the DNA replication apparatus of human breast cancer cells mediates an error-prone (mutagenic) DNA synthetic process. She was also able to correlate acquisition of a mutagenic DNA replication mechanism in breast cancer with a modification of a specific protein in the DNA synthetic apparatus. Dr. Malkas is evaluating this protein as a potential biomarker for breast cancer and as a target for cancer therapy. Dr. Malkas attained the rank of Full Professor at the University of Maryland in July 2001. In January 2002 Dr. Malkas joined the faculty at the Indiana University School of Medicine as a Professor of Medicine, and was named the Vera Bradley Chair for Oncology.
In March Dr. Malkas was named the co-leader of the Indiana University Cancer Center's Hormone and Reproductive Oncology Program. In 2006, she was given the additional title of Professor of Surgery. Dr. Malkas has been invited to participate in a variety of National Institutes of Health (NIH) and Department of Defense (DOD) grant review study sections. These include: permanent membership on the NIH Experimental Therapies I (1994-1998) and the Cancer Molecular Pathobiology Study Sections (2003-2007), a variety of NIH Program Project Review Committees and special review panels, a number of DOD Breast Cancer Program grant review panels and chairing a DOD ovarian program project review panel (Sept. 2001).